Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells

The PRC2 complex protein EZH2 is a histone methyltransferase that is known to bind and recruit DNMT1 to the DNA to modulate DNA methylation. Here, we determined that the pan-HDAC inhibitor panobinostat (LBH589) treatment depletes DNMT1 and EZH2 protein levels, disrupts the interaction of DNMT1 with...

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Main Authors: Fiskus, Warren, Buckley, Kate, Rao, Rekha, Mandawat, Aditya, Yang, Yonghua, Joshi, Rajeshree, Wang, Yongchao, Balusu, Ramesh, Chen, Jianguang, Koul, Sanjay, Joshi, Atul, Upadhyay, Sunil, Atadja, Peter, Bhalla, Kapil N.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775142/
https://ncbi.nlm.nih.gov/pubmed/19279403
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