Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

Amyloid β-peptide (Aβ) has a central role in the pathogenesis of Alzheimer’s disease (AD). Cellular cholesterol homeostasis regulates endoproteolytic generation of Aβ from the amyloid precursor protein (APP). Previous studies have identified acyl-coenzyme A: cholesterol acyltransferase (ACAT), an en...

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Hlavní autoři: Huttunen, Henri J., Peach, Camilla, Bhattacharyya, Raja, Barren, Cory, Pettingell, Warren, Hutter-Paier, Birgit, Windisch, Manfred, Berezovska, Oksana, Kovacs, Dora M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2009
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2775008/
https://ncbi.nlm.nih.gov/pubmed/19625658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-134999
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