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Active site determinants of substrate recognition by the metalloproteinases TACE and ADAM10

The metalloproteinases TACE (ADAM17) and ADAM10 are the primary enzymes responsible for catalyzing release of membrane anchored proteins from the cell surface in metazoan organisms. While the repertoire of protein substrates for these two proteases is partially overlapping, each one appears to targe...

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Bibliografische gegevens
Hoofdauteurs: Caescu, Cristina I., Jeschke, Grace R., Turk, Benjamin E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774824/
https://ncbi.nlm.nih.gov/pubmed/19715556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20090549
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