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The metalloproteinase ADAM10 requires its activity to sustain surface expression

The metalloproteinase ADAM10 critically contributes to development, inflammation, and cancer and can be controlled by endogenous or synthetic inhibitors. Here, we demonstrate for the first time that loss of proteolytic activity of ADAM10 by either inhibition or loss of function mutations induces rem...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Mol Life Sci
Hauptverfasser: Seifert, Anke, Düsterhöft, Stefan, Wozniak, Justyna, Koo, Chek Z., Tomlinson, Michael G., Nuti, Elisa, Rossello, Armando, Cuffaro, Doretta, Yildiz, Daniela, Ludwig, Andreas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7873107/
https://ncbi.nlm.nih.gov/pubmed/32372373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03507-w
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