Homogenous Fluorescent Assays for Characterizing Small-Molecule Activators of AMP-Activated Protein Kinase (AMPK)

AMP activated protein kinase (AMPK) is a key regulator of cellular metabolism. AMPK activity is modulated in part by binding of AMP to the γ-subunit of the kinase, which increases the activity of the catalytic α-subunit. Because increased AMPK activity in the liver and in skeletal muscle leads to in...

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Autori principali: Reichling, Laurie J, Riddle, Steven M, Mei, Baigen, Bruinsma, Rica, Goossens, Tony A, Huwiler, Kristin G, Maffitt, Mark, Newport, Alyssa M.G, Qian, Xiao-Dong, Ruttimann-Johnson, Carmen, Vogel, Kurt W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Bentham Science Publishers Ltd. 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774621/
https://ncbi.nlm.nih.gov/pubmed/20161826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1875397300801010034
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