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Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells

Premature termination codon (PTC) mutations are due to insertion or deletion of nucleotides causing a frameshift and premature termination codon in RNA. These transcripts are degraded by the nonsense-mediated decay pathway and have a very short half-life. We used a microarray technique to screen for...

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Autors principals: Sharma, Sanjai, Lichtenstein, Alan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774554/
https://ncbi.nlm.nih.gov/pubmed/19745069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-206482
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