miRNA deregulation by epigenetic silencing disrupts suppression of the oncogene PLAG1 in chronic lymphocytic leukemia

MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL patients and peripheral B cells of 14 healthy donors were applied to miRNA expressi...

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Bibliografische gegevens
Hoofdauteurs: Pallasch, Christian Philipp, Patz, Michaela, Park, Yoon Jung, Hagist, Susanne, Eggle, Daniela, Claus, Rainer, Debey-Pascher, Svenja, Schulz, Alexandra, Frenzel, Lukas P., Claasen, Julia, Kutsch, Nadine, Krause, Günter, Mayr, Christine, Rosenwald, Andreas, Plass, Christoph, Schultze, Joachim L., Hallek, Michael, Wendtner, Clemens-Martin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2009
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2925729/
https://ncbi.nlm.nih.gov/pubmed/19692702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-06-229898
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