In vivo prostaglandin E(2) treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells

Microenvironmental signals can determine hematopoietic stem cell (HSC) fate choices both directly and through stimulation of niche cells. In the bone marrow, prostaglandin E(2) (PGE(2)) is known to affect both osteoblasts and osteoclasts, whereas in vitro it expands HSCs and affects differentiation...

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Detalhes bibliográficos
Main Authors: Frisch, Benjamin J., Porter, Rebecca L., Gigliotti, Benjamin J., Olm-Shipman, Adam J., Weber, Jonathan M., O'Keefe, Regis J., Jordan, Craig T., Calvi, Laura M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774547/
https://ncbi.nlm.nih.gov/pubmed/19726721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-205823
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