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Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods

We describe the use of racemic crystallography to determine the X-ray structure of the natural product plectasin, a potent antimicrobial protein recently isolated from fungus. The protein enantiomers l-plectasin and d-plectasin were prepared by total chemical synthesis; interestingly, l-plectasin sh...

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Bibliografiske detaljer
Main Authors: Mandal, Kalyaneswar, Pentelute, Brad L, Tereshko, Valentina, Thammavongsa, Vilasak, Schneewind, Olaf, Kossiakoff, Anthony A, Kent, Stephen B H
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774425/
https://ncbi.nlm.nih.gov/pubmed/19472324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.127
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