Virus neutralization by germ-line vs. hypermutated antibodies

Mice infected with vesicular stomatitis virus (VSV), a cytopathic virus closely related to rabies virus, mount a virus-neutralizing antibody response protecting against lethal disease. VSVneutralizing monoclonal IgGs isolated from primary immune responses were devoid of somatic mutations, whereas mo...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Kalinke, Ulrich, Oxenius, Annette, López-Macías, Constantino, Zinkernagel, Rolf M., Hengartner, Hans
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 2000
Materias:	Biological Sciences
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27744/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10963674/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.18.10126
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