Virus neutralization by germ-line vs. hypermutated antibodies

Mice infected with vesicular stomatitis virus (VSV), a cytopathic virus closely related to rabies virus, mount a virus-neutralizing antibody response protecting against lethal disease. VSVneutralizing monoclonal IgGs isolated from primary immune responses were devoid of somatic mutations, whereas mo...

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Bibliografiske detaljer
Main Authors: Kalinke, Ulrich, Oxenius, Annette, López-Macías, Constantino, Zinkernagel, Rolf M., Hengartner, Hans
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC27744/
https://ncbi.nlm.nih.gov/pubmed/10963674
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