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Optical Detection of Disordered Water Within a Protein Cavity

Internal water molecules are important to protein structure and function, but positional disorder and low occupancies can obscure their detection by x-ray crystallography. Here we show that water can be detected within the distal cavities of myoglobin mutants by subtle changes in the absorbance spec...

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Autori principali: Goldbeck, Robert A., Pillsbury, Marlisa L., Jensen, Russell A., Mendoza, Juan L., Nguyen, Rosa L., Olson, John S., Soman, Jayashree, Kliger, David S., Esquerra, Raymond M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774273/
https://ncbi.nlm.nih.gov/pubmed/19655795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja903409j
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