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Is Resistance Useless? Multidrug Resistance and Collateral Sensitivity
When cancer cells develop resistance to chemotherapeutics, it is frequently conferred by the ATP-dependent efflux pump P-glycoprotein (MDR1, P-gp, ABCB1). P-gp can efflux a wide range of cancer drugs; thus its expression confers cross-resistance, termed multidrug resistance (MDR), to a wide range of...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2774243/ https://ncbi.nlm.nih.gov/pubmed/19762091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2009.07.003 |
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