Transcription Factors Krüppel-Like Factor 6 and Peroxisome Proliferator-Activated Receptor-γ Mediate High Glucose-Induced Thioredoxin-Interacting Protein

We demonstrated recently that thioredoxin-interacting protein (Txnip) and the transcription factor Krüppel-like factor 6 (KLF6) were up-regulated in both in vivo and in vitro models of diabetic nephropathy, thus promoting renal injury. Conversely, peroxisome proliferator-activated receptor-γ (PPAR-γ...

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Autores principales: Qi, Weier, Chen, Xinming, Holian, John, Tan, Christina Y.R., Kelly, Darren J., Pollock, Carol A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2009
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Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774051/
https://ncbi.nlm.nih.gov/pubmed/19808645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090263
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