Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved in salt and fluid transport in multiple organs, including the lung. Most CF mutations eithe...

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Bibliografiset tiedot
Päätekijät: Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D. J., Burton, Bill, Cao, Dong, Neuberger, Tim, Turnbull, Amanda, Singh, Ashvani, Joubran, John, Hazlewood, Anna, Zhou, Jinglan, McCartney, Jason, Arumugam, Vijayalaksmi, Decker, Caroline, Yang, Jennifer, Young, Chris, Olson, Eric R., Wine, Jeffery J., Frizzell, Raymond A., Ashlock, Melissa, Negulescu, Paul
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2009
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773991/
https://ncbi.nlm.nih.gov/pubmed/19846789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904709106
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