Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated epithelial anion channel involved in salt and fluid transport in multiple organs, including the lung. Most CF mutations eithe...

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Main Authors: Van Goor, Fredrick, Hadida, Sabine, Grootenhuis, Peter D. J., Burton, Bill, Cao, Dong, Neuberger, Tim, Turnbull, Amanda, Singh, Ashvani, Joubran, John, Hazlewood, Anna, Zhou, Jinglan, McCartney, Jason, Arumugam, Vijayalaksmi, Decker, Caroline, Yang, Jennifer, Young, Chris, Olson, Eric R., Wine, Jeffery J., Frizzell, Raymond A., Ashlock, Melissa, Negulescu, Paul
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2009
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773991/
https://ncbi.nlm.nih.gov/pubmed/19846789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904709106
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