Triptolide Inhibits the Proliferation of Immortalized HT22 Hippocampal Cells Via Persistent Activation of Extracellular Signal-Regulated Kinase-1/2 by Down-Regulating Mitogen-Activated Protein Kinase Phosphatase-1 Expression

OBJECTIVE: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulated kinase-1/2 (ERK-1/2), the p38 MAPK and the c-Jun N-terminal kinase-1/2 (JNK-1/2), and t...

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Main Authors: Koo, Hee Sang, Kang, Sung Don, Lee, Ju Hwan, Kim, Nam-Ho, Chung, Hun-Taeg, Pae, Hyun-Ock
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Neurosurgical Society 2009
Assuntos:
Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2773400/
https://ncbi.nlm.nih.gov/pubmed/19893732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3340/jkns.2009.46.4.389
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