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Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by motor neuron degeneration. Mutations in Cu,Zn-superoxide dismutase (SOD1) are responsible for 20% of familial ALS cases via a toxic gain of function. In mutant SOD1 transgenic mice, mitochondria of spinal motor neu...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2773270/ https://ncbi.nlm.nih.gov/pubmed/19779023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp421 |
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