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Lysyl-tRNA Synthetase Is a Target for Mutant SOD1 Toxicity in Mitochondria
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease affecting the motor neurons. The majority of familial forms of ALS are caused by mutations in the Cu,Zn-superoxide dismutase (SOD1). In mutant SOD1 spinal cord motor neurons, mitochondria develop abnormal morphology, bioe...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568925/ https://ncbi.nlm.nih.gov/pubmed/18715867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805599200 |
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