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Running in reverse: the structural basis for translocation polarity in hexameric helicases

Hexameric helicases couple ATP hydrolysis to processive separation of nucleic acid duplexes, a process critical for gene expression, DNA replication and repair. All hexameric helicases fall into two families with opposing translocation polarities: the 3’→5’ AAA+ and 5’→3’ RecA-like enzymes. To under...

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Autors principals: Thomsen, Nathan D., Berger, James M.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772833/
https://ncbi.nlm.nih.gov/pubmed/19879839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.08.043
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