The Small Molecule GMX1778 Is a Potent Inhibitor of NAD(+) Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

GMX1777 is a prodrug of the small molecule GMX1778, currently in phase I clinical trials for the treatment of cancer. We describe findings indicating that GMX1778 is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT). Cancer cells have a...

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Main Authors: Watson, Mark, Roulston, Anne, Bélec, Laurent, Billot, Xavier, Marcellus, Richard, Bédard, Dominique, Bernier, Cynthia, Branchaud, Stéphane, Chan, Helen, Dairi, Kenza, Gilbert, Karine, Goulet, Daniel, Gratton, Michel-Olivier, Isakau, Henady, Jang, Anne, Khadir, Abdelkrim, Koch, Elizabeth, Lavoie, Manon, Lawless, Michael, Nguyen, Mai, Paquette, Denis, Turcotte, Émilie, Berger, Alvin, Mitchell, Matthew, Shore, Gordon C., Beauparlant, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772749/
https://ncbi.nlm.nih.gov/pubmed/19703994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00112-09
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