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Electropositive Charge in α-Defensin Bactericidal Activity: Functional Effects of Lys-for-Arg Substitutions Vary with the Peptide Primary Structure
Cationic amino acids contribute to α-defensin bactericidal activity. Curiously, although Arg and Lys have equivalent electropositive charges at neutral pH, α-defensins contain an average of nine Arg residues per Lys residue. To investigate the role of high α-defensin Arg content, all Arg residues in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772546/ https://ncbi.nlm.nih.gov/pubmed/19737896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00695-09 |
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