Characterization of Two Seryl-tRNA Synthetases in Albomycin-Producing Streptomyces sp. Strain ATCC 700974

The Trojan horse antibiotic albomycin, produced by Streptomyces sp. strain ATCC 700974, contains a thioribosyl nucleoside moiety linked to a hydroxamate siderophore through a serine residue. The seryl nucleoside structure (SB-217452) is a potent inhibitor of seryl-tRNA synthetase (SerRS) in the path...

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Bibliografische gegevens
Hoofdauteurs: Zeng, Yu, Roy, Hervé, Patil, Preeti B., Ibba, Michael, Chen, Shawn
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
Onderwerpen:
Chemistry; Biosynthesis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772349/
https://ncbi.nlm.nih.gov/pubmed/19721072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00782-09
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