CS-8958, a Prodrug of the Novel Neuraminidase Inhibitor R-125489, Demonstrates a Favorable Long-Retention Profile in the Mouse Respiratory Tract

CS-8958 is a prodrug of the pharmacologically active form R-125489, a selective neuraminidase inhibitor, and has long-acting anti-influenza virus activity in vivo. In this study, the tissue distribution profiles after a single intranasal administration of CS-8958 (0.5 μmol/kg of body weight) to mice...

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Hlavní autoři: Koyama, Kumiko, Takahashi, Makoto, Oitate, Masataka, Nakai, Naoko, Takakusa, Hideo, Miura, Shin-ichi, Okazaki, Osamu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772300/
https://ncbi.nlm.nih.gov/pubmed/19687241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00731-09
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