Interaction of Polycyclic Aromatic Hydrocarbons with Human Cytochrome P450 1B1 in Inhibiting Catalytic Activity

Eleven polycyclic aromatic hydrocarbons (PAHs) and 14 acetylenic PAHs and biphenyls were used to analyze interactions with cytochrome P450 (P450) 1B1 in inhibiting catalytic activity, using 7-ethoxyresorufin O-deethylation (EROD) as a model reaction. Most of the chemicals examined were direct inhibi...

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Detalhes bibliográficos
Main Authors: Shimada, Tsutomu, Murayama, Norie, Tanaka, Katsuhiro, Takenaka, Shigeo, Imai, Yoshio, Hopkins, Nancy E., Foroozesh, Maryam K., Alworth, Willam L., Yamazaki, Hiroshi, Guengerich, F. Peter, Komori, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772130/
https://ncbi.nlm.nih.gov/pubmed/19548353
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