Structure-Function Relationships of Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 Flavonoid Derivatives

Structure-function relationships for inhibition of human cytochrome P450s (P450s) 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives were studied. Thirty-two of the 33 flavonoids tested produced Reverse Type I binding spectra with P450 1B1, and the potencies of binding were correlated with the...

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Detalhes bibliográficos
Main Authors: Shimada, Tsutomu, Tanaka, Katsuhiro, Takenaka, Shigeo, Murayama, Norie, Martin, Martha V., Foroozesh, Maryam K., Yamazaki, Hiroshi, Guengerich, F. Peter, Komori, Masayuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072440/
https://ncbi.nlm.nih.gov/pubmed/21053930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100286d
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