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IgG-Paraoxonase-1 Fusion Protein for Targeted Drug Delivery Across the Human Blood-Brain Barrier

Paraoxonase (PON)-1 is the most potent human protein with organophosphatase activity against organophosphate (OP) toxins. OP compounds readily cross the blood-brain barrier (BBB), and have lethal mechanisms of action within the brain. The production of a brain penetrating form of human PON1, which c...

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Bibliographic Details
Main Authors: Boado, Ruben J., Zhang, Yun, Zhang, Yufeng, Wang, Yuntao, Pardridge, William M.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771892/
https://ncbi.nlm.nih.gov/pubmed/19434854
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