IgG-Paraoxonase-1 Fusion Protein for Targeted Drug Delivery Across the Human Blood-Brain Barrier

Paraoxonase (PON)-1 is the most potent human protein with organophosphatase activity against organophosphate (OP) toxins. OP compounds readily cross the blood-brain barrier (BBB), and have lethal mechanisms of action within the brain. The production of a brain penetrating form of human PON1, which c...

Full description

Saved in:
Bibliographic Details
Main Authors: Boado, Ruben J., Zhang, Yun, Zhang, Yufeng, Wang, Yuntao, Pardridge, William M.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771892/
https://ncbi.nlm.nih.gov/pubmed/19434854
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items