C-Lysine Conjugates: pH-Controlled Light-Activated Reagents for Efficient Double Stranded DNA Cleavage with Implications for Cancer Therapy

Double-stranded DNA cleavage of light-activated lysine conjugates is strongly enhanced at the slightly acidic pH (<7) suitable for selective targeting of cancer cells. This enhancement stems from the presence of two amino groups of different basicities. The first amino group plays an auxiliary ro...

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Main Authors: Yang, Wang-Yong, Breiner, Boris, Kovalenko, Serguei V., Ben, Chi, Singh, Mani, LeGrand, Shauna N., Sang, Qing-Xiang Amy, Strouse, Geoffrey F., Copland, John A., Alabugin, Igor V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771568/
https://ncbi.nlm.nih.gov/pubmed/19637922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja902140m
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