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Targeted Deletion of p73 in Mice Reveals Its Role in T Cell Development and Lymphomagenesis

Transcriptional silencing of the p73 gene through methylation has been demonstrated in human leukemias and lymphomas. However, the role of p73 in the malignant process remains to be explored. We show here that p73 acts as a T cell-specific tumor suppressor in a genetically defined mouse model, and t...

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Autors principals: Nemajerova, Alice, Palacios, Gustavo, Nowak, Norma J., Matsui, Sei-ichi, Petrenko, Oleksi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771421/
https://ncbi.nlm.nih.gov/pubmed/19907659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007784
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