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Targeted Deletion of p73 in Mice Reveals Its Role in T Cell Development and Lymphomagenesis

Transcriptional silencing of the p73 gene through methylation has been demonstrated in human leukemias and lymphomas. However, the role of p73 in the malignant process remains to be explored. We show here that p73 acts as a T cell-specific tumor suppressor in a genetically defined mouse model, and t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Nemajerova, Alice, Palacios, Gustavo, Nowak, Norma J., Matsui, Sei-ichi, Petrenko, Oleksi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771421/
https://ncbi.nlm.nih.gov/pubmed/19907659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007784
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