Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody

Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X-ray crystallography we have defined the structure of the flavivirus cross-reactive antibody E53 that engages the highly conserved fus...

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Main Authors: Cherrier, Mickaël V, Kaufmann, Bärbel, Nybakken, Grant E, Lok, Shee-Mei, Warren, Julia T, Chen, Beverly R, Nelson, Christopher A, Kostyuchenko, Victor A, Holdaway, Heather A, Chipman, Paul R, Kuhn, Richard J, Diamond, Michael S, Rossmann, Michael G, Fremont, Daved H
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771083/
https://ncbi.nlm.nih.gov/pubmed/19713934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.245
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