AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis

BACKGROUND: Gossypol, a naturally occurring polyphenolic compound has been identified as a small molecule inhibitor of anti-apoptotic Bcl-2 family proteins. It induces apoptosis in a wide range of tumor cell lines and enhances chemotherapy- and radiation-induced cytotoxicity both in vitro and in viv...

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Detalhes bibliográficos
Principais autores: Zerp, Shuraila F, Stoter, Rianne, Kuipers, Gitta, Yang, Dajun, Lippman, Marc E, van Blitterswijk, Wim J, Bartelink, Harry, Rooswinkel, Rogier, Lafleur, Vincent, Verheij, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771029/
https://ncbi.nlm.nih.gov/pubmed/19852810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-4-47
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