Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts

The ALP (alkyl-lysophospholipid) edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine; Et-18-OCH(3)) induces apoptosis in S49 mouse lymphoma cells. To this end, ALP is internalized by lipid raft-dependent endocytosis and inhibits phosphatidylcholine synthesis. A variant cell-line, S49(A...

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Detalhes bibliográficos
Main Authors: Van der Luit, Arnold H., Budde, Marianne, Zerp, Shuraila, Caan, Wendy, Klarenbeek, Jeffrey B., Verheij, Marcel, van Blitterswijk, Wim J.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820802/
https://ncbi.nlm.nih.gov/pubmed/17049047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061178
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