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Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine
Peptide nucleic acid (PNA) is a successful DNA/RNA mimic. A major challenge for research is to invent chemically modified PNAs that retain the favorable properties of the parent compound while improving biological recognition. Here we test modified PNAs containing [bis-o-(aminoethoxy)phenyl]pyrroloc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2770837/ https://ncbi.nlm.nih.gov/pubmed/19783436 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.09.004 |
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