Distinct Conformations of Ly49 Natural Killer Cell Receptors Mediate MHC Class I Recognition in Trans and Cis

Certain cell surface receptors engage ligands expressed on juxtaposed cells, but also ligands on the same cell. The structural basis for trans versus cis binding is not known. Here, we show that Ly49 natural killer (NK) cell receptors bind two MHC class I (MHC-I) molecules in trans when the two liga...

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Bibliographic Details
Main Authors: Back, Jonathan, Malchiodi, Emilio L., Cho, Sangwoo, Scarpellino, Léonardo, Schneider, Pascal, Kerzic, Melissa C., Mariuzza, Roy A., Held, Werner
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770797/
https://ncbi.nlm.nih.gov/pubmed/19818651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.007
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