Distinct Conformations of Ly49 Natural Killer Cell Receptors Mediate MHC Class I Recognition in Trans and Cis

Certain cell surface receptors engage ligands expressed on juxtaposed cells, but also ligands on the same cell. The structural basis for trans versus cis binding is not known. Here, we show that Ly49 natural killer (NK) cell receptors bind two MHC class I (MHC-I) molecules in trans when the two liga...

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Main Authors: Back, Jonathan, Malchiodi, Emilio L., Cho, Sangwoo, Scarpellino, Léonardo, Schneider, Pascal, Kerzic, Melissa C., Mariuzza, Roy A., Held, Werner
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770797/
https://ncbi.nlm.nih.gov/pubmed/19818651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.007
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