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Cutting Edge: Selective Tyrosine Dephosphorylation of Interferon-Activated Nuclear STAT5 by the VHR Phosphatase

Cytokine-induced tyrosine phosphorylation of the transcription factor STAT5 is required for its transcriptional activity. In this article we show that the small dual-specificity phosphatase VHR selectively dephosphorylates IFN-α- and β-activated, tyrosine-phosphorylated STAT5, leading to the subsequ...

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Detalhes bibliográficos
Main Authors: Hoyt, Richard, Zhu, Wei, Cerignoli, Fabio, Alonso, Andres, Mustelin, Tomas, David, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770724/
https://ncbi.nlm.nih.gov/pubmed/17785772
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