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Solution and Crystal Molecular Dynamics Simulation Study of m4-Cyanovirin-N Mutants Complexed with Di-Mannose

Cyanovirin-N (CVN) is a highly potent anti-HIV carbohydrate-binding agent that establishes its microbicide activity through interaction with mannose-rich glycoprotein gp120 on the virion surface. The m4-CVN and P51G-m4-CVN mutants represent simple models for studying the high-affinity binding site,...

詳細記述

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書誌詳細
主要な著者: Vorontsov, Ivan I., Miyashita, Osamu
フォーマット: Artigo
言語:Inglês
出版事項: The Biophysical Society 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770623/
https://ncbi.nlm.nih.gov/pubmed/19883596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.08.011
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