Inhibition of HIV-1 gene expression by Ciclopirox and Deferiprone, drugs that prevent hypusination of eukaryotic initiation factor 5A

BACKGROUND: Eukaryotic translation initiation factor eIF5A has been implicated in HIV-1 replication. This protein contains the apparently unique amino acid hypusine that is formed by the post-translational modification of a lysine residue catalyzed by deoxyhypusine synthase and deoxyhypusine hydroxy...

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Main Authors: Hoque, Mainul, Hanauske-Abel, Hartmut M, Palumbo, Paul, Saxena, Deepti, D'Alliessi Gandolfi, Darlene, Park, Myung Hee, Pe'ery, Tsafi, Mathews, Michael B
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770518/
https://ncbi.nlm.nih.gov/pubmed/19825182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-90
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