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Insight to pyrazinamide resistance inMycobacterium tuberculosisby molecular docking

Pyrazinamide (PZA) - an important drug in the anti-tuberculosis therapy, activated by an enzyme Pyrazinamidase (PZase). The basis of PZA resistance in Mycobacterium tuberculosis was owing to mutation in pncA gene coding for PZase. Homology modeling of PZase was performed using software Discovery Stu...

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Bibliografiske detaljer
Main Authors: Unissa, Amirudeen Nusrath, Selvakumar, Nagamiah, Hassan, Sameer
Format: Artigo
Sprog:Inglês
Udgivet: Biomedical Informatics 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770367/
https://ncbi.nlm.nih.gov/pubmed/20011149
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