Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system

Ho endonuclease of Saccharomyces cerevisiae is a homing endonuclease that makes a site-specific double-strand break in the MAT gene in late G(1). Here we show that Ho is rapidly degraded via the ubiquitin-26S proteasome system through two ubiquitin-conjugating enzymes UBC2(Rad6) and UBC3(Cdc34). UBC...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kaplun, Ludmila, Ivantsiv, Yelena, Kornitzer, Daniel, Raveh, Dina
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10963670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.18.10077
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