Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic acinar cell responses of this disease are vacuole accumulation and trypsinogen activation. We show here that both result from defective autophagy, by comparing the autophagic responses in rodent models of acute...

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Detaylı Bibliyografya
Asıl Yazarlar: Mareninova, Olga A., Hermann, Kip, French, Samuel W., O’Konski, Mark S., Pandol, Stephen J., Webster, Paul, Erickson, Ann H., Katunuma, Nobuhiko, Gorelick, Fred S., Gukovsky, Ilya, Gukovskaya, Anna S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2009
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769194/
https://ncbi.nlm.nih.gov/pubmed/19805911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38674
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