Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

The pathogenic mechanisms underlying acute pancreatitis are not clear. Two key pathologic acinar cell responses of this disease are vacuole accumulation and trypsinogen activation. We show here that both result from defective autophagy, by comparing the autophagic responses in rodent models of acute...

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Detalhes bibliográficos
Main Authors: Mareninova, Olga A., Hermann, Kip, French, Samuel W., O’Konski, Mark S., Pandol, Stephen J., Webster, Paul, Erickson, Ann H., Katunuma, Nobuhiko, Gorelick, Fred S., Gukovsky, Ilya, Gukovskaya, Anna S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769194/
https://ncbi.nlm.nih.gov/pubmed/19805911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38674
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