Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggest...

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Main Authors: VI, James G. Taylor, Cheuk, Adam T., Tsang, Patricia S., Chung, Joon-Yong, Song, Young K., Desai, Krupa, Yu, Yanlin, Chen, Qing-Rong, Shah, Kushal, Youngblood, Victoria, Fang, Jun, Kim, Su Young, Yeung, Choh, Helman, Lee J., Mendoza, Arnulfo, Ngo, Vu, Staudt, Louis M., Wei, Jun S., Khanna, Chand, Catchpoole, Daniel, Qualman, Stephen J., Hewitt, Stephen M., Merlino, Glenn, Chanock, Stephen J., Khan, Javed
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769177/
https://ncbi.nlm.nih.gov/pubmed/19809159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39703
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