Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models

Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggest...

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Hlavní autoři: VI, James G. Taylor, Cheuk, Adam T., Tsang, Patricia S., Chung, Joon-Yong, Song, Young K., Desai, Krupa, Yu, Yanlin, Chen, Qing-Rong, Shah, Kushal, Youngblood, Victoria, Fang, Jun, Kim, Su Young, Yeung, Choh, Helman, Lee J., Mendoza, Arnulfo, Ngo, Vu, Staudt, Louis M., Wei, Jun S., Khanna, Chand, Catchpoole, Daniel, Qualman, Stephen J., Hewitt, Stephen M., Merlino, Glenn, Chanock, Stephen J., Khan, Javed
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2009
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769177/
https://ncbi.nlm.nih.gov/pubmed/19809159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39703
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