Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas

Fibroblast growth factor receptor 4 (FGFR4) aberrant expression and activity have been linked to the pathogenesis of a variety of cancers including rhabdomyosarcomas (RMS). We found that treatment of alveolar rhabdomyosarcoma (aRMS) cells with Guadecitabine (SGI-110), a next-generation DNA methyltra...

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Veröffentlicht in:Neoplasia
Hauptverfasser: Darvishi, Emad, Slemmons, Katherine, Wan, Zesheng, Mitra, Sheetal, Hou, Xiaogang, Hugues Parmentier, Jean, Eddie Loh, Yong-Hwee, Helman, Lee J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2020
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251315/
https://ncbi.nlm.nih.gov/pubmed/32464274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2020.05.001
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