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HIV-1 Integrase Interaction with U3 and U5 Terminal Sequences in Vitro Defined Using Substrates with Random Sequences

Successful integration of viral genome into a host chromosome depends on interaction between viral integrase and its recognition sequences. We have used a reconstituted concerted human immunodeficiency virus, type 1 (HIV-1), integration system to analyze the role of integrase (IN) recognition sequen...

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Bibliographic Details
Main Authors: Brin, Elena, Leis, Jonathan
Format: Artigo
Language:Inglês
Published: 2002
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769074/
https://ncbi.nlm.nih.gov/pubmed/11897790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M201354200
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