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Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity

Cyclin-dependent kinase (Cdk) 5 reduces the rewarding properties of psychostimulants by dampening postsynaptic dopamine (DA) receptor signaling. Cdk5 is also present in midbrain DA neurons, where the DA transporter (DAT) is localized and limits DA neurotransmission by removing extracellular DA. Here...

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Detalles Bibliográficos
Main Authors: Price, David A., Sorkin, Alexander, Zahniser, Nancy R.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769044/
https://ncbi.nlm.nih.gov/pubmed/19628755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056978
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