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Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity
Cyclin-dependent kinase (Cdk) 5 reduces the rewarding properties of psychostimulants by dampening postsynaptic dopamine (DA) receptor signaling. Cdk5 is also present in midbrain DA neurons, where the DA transporter (DAT) is localized and limits DA neurotransmission by removing extracellular DA. Here...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2769044/ https://ncbi.nlm.nih.gov/pubmed/19628755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056978 |
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