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Cyclin-Dependent Kinase 5 Inhibitors: Inhibition of Dopamine Transporter Activity

Cyclin-dependent kinase (Cdk) 5 reduces the rewarding properties of psychostimulants by dampening postsynaptic dopamine (DA) receptor signaling. Cdk5 is also present in midbrain DA neurons, where the DA transporter (DAT) is localized and limits DA neurotransmission by removing extracellular DA. Here...

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Autors principals: Price, David A., Sorkin, Alexander, Zahniser, Nancy R.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769044/
https://ncbi.nlm.nih.gov/pubmed/19628755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056978
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