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IL-27 induces the transcription factor c-Maf, cytokine IL-21 and costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells
IL-27 has recently been identified as a differentiation factor for the generation of IL-10-producing regulatory type 1 (Tr1) T cells. However, how IL-27 induces the expansion of Tr1 cells has not been elucidated. Here we demonstrate that IL-27 drives expansion and differentiation of IL-10-producing...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2768608/ https://ncbi.nlm.nih.gov/pubmed/19570826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901233 |
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