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IL-27 induces the transcription factor c-Maf, cytokine IL-21 and costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

IL-27 has recently been identified as a differentiation factor for the generation of IL-10-producing regulatory type 1 (Tr1) T cells. However, how IL-27 induces the expansion of Tr1 cells has not been elucidated. Here we demonstrate that IL-27 drives expansion and differentiation of IL-10-producing...

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Autors principals: Pot, Caroline, Jin, Hulin, Awasthi, Amit, Liu, Sue Min, Lai, Chen-Yen, Madan, Rajat, Sharpe, Arlene H., Karp, Christopher L., Miaw, Shi-Chuen, Ho, I-Cheng, Kuchroo, Vijay K.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768608/
https://ncbi.nlm.nih.gov/pubmed/19570826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0901233
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