Differential induction of Id3 signals lineage divergence, Notch-independent differentiation, and functional maturation of γδ T cells

αβ and γδ T-cells arise from a common thymocyte progenitor during development in the thymus. Emerging evidence suggests that the pre-T cell receptor (pre-TCR) and γδ T-cell receptor (γδTCR) play instructional roles in specifying the αβ and γδ T-lineage fates, respectively. Nevertheless, the signalin...

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Detalhes bibliográficos
Main Authors: Lauritsen, Jens Peter Holst, Wong, Gladys W., Lee, Sang-Yun, Lefebvre, Juliette M., Ciofani, Maria, Rhodes, Michele, Kappes, Dietmar J., Zúñiga-Pflücker, Juan Carlos, Wiest, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768560/
https://ncbi.nlm.nih.gov/pubmed/19833086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.07.010
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